Maria João Gama Selected Research

Parkinson Disease (Parkinson's Disease)

1/2024	Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease.
12/2023	NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.
12/2018	Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease.
1/2017	Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease.
1/2017	Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease.
4/2013	Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.
6/2009	GSTpi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum.

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Maria João Gama Research Topics

Disease

7	Parkinson Disease (Parkinson's Disease) 01/2024 - 06/2009
7	Neuroblastoma 12/2023 - 02/2009
4	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 01/2013
4	Mitochondrial Diseases (Mitochondrial Disease) 12/2018 - 01/2017
3	Neuroinflammatory Diseases 07/2021 - 12/2018
2	Neoplasms (Cancer) 08/2023 - 03/2022
1	Inflammation (Inflammations) 01/2024
1	Lipidoses 12/2023
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 12/2023
1	Weight Loss (Weight Reduction) 12/2023
1	Hepatomegaly 12/2023
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 03/2022
1	Multiple Myeloma 03/2022
1	Hematologic Neoplasms (Hematological Malignancy) 03/2022
1	Parkinsonian Disorders (Parkinsonism) 12/2018
1	Tremor (Tremors) 12/2018
1	Alzheimer Disease (Alzheimer's Disease) 01/2010
1	Huntington Disease (Huntington's Disease) 07/2008

Drug/Important Bio-Agent (IBA)

6	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 12/2023 - 06/2009
6	ursodoxicoltaurineIBA 01/2019 - 01/2017
5	Cholesterol 24-Hydroxylase (CYP46A1)IBA 12/2023 - 01/2010
4	CholesterolIBA 12/2023 - 07/2008
3	Proteins (Proteins, Gene)FDA Link 01/2024 - 02/2009
2	Proteasome InhibitorsIBA 08/2023 - 03/2022
2	AntioxidantsIBA 01/2019 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 06/2009
2	theasinensin AIBA 01/2013 - 09/2012
1	Sialyl Lewis X AntigenIBA 01/2024
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2023
1	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA 12/2023
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2023
1	UbiquitinIBA 08/2023
1	EnzymesIBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 12/2018
1	Oxidoreductases (Dehydrogenase)IBA 01/2015
1	Histone Deacetylase InhibitorsIBA 01/2013
1	trichostatin A (A 300)IBA 01/2013
1	MitogensIBA 09/2012
1	Histones (Histone)IBA 09/2012
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 09/2012
1	Phosphotransferases (Kinase)IBA 09/2012
1	Okadaic AcidIBA 09/2012
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 09/2012
1	Glutathione S-Transferase piIBA 02/2009

Therapy/Procedure

1	Therapeutics 03/2022